Weight & Metabolism
GLP-1 drugs, next-generation incretins and research peptides for fat loss and metabolic health.
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Mazdutide vs Survodutide vs Retatrutide: differences, evidence and safety
Mazdutide is already approved in China for weight management and type 2 diabetes; survodutide has the strongest liver-disease data, including biopsy-confirmed MASH improvement; retatrutide…
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Peptides vs Ozempic: what the evidence shows, and why Ozempic is a peptide too
Ozempic is itself a peptide drug: its active ingredient, semaglutide, is a GLP-1 analog whose “peptide backbone is produced by yeast fermentation” (Ozempic label).…
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Tesamorelin results timeline: what trials measured, week by week
Tesamorelin results in trials were measured in weeks and months: blood growth hormone and IGF-1 rose within 2 weeks, while the main result, less…
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SLU-PP-332 vs MOTS-c: differences, evidence and safety
SLU-PP-332 is a lab-made “exercise mimetic” that made mice run about 70% longer (Billon 2023); MOTS-c is a natural mitochondrial peptide that improved running…
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AOD-9604 vs Tesamorelin: differences, evidence and safety
Tesamorelin, FDA-approved as Egrifta, cut deep belly fat by 15.2% in a 412-person phase 3 trial in people with HIV. AOD-9604, a growth-hormone fragment,…
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Peptides for weight loss: approved GLP-1 drugs vs research peptides, ranked by evidence
The best-researched peptides for weight loss are FDA-approved GLP-1 drugs: tirzepatide (Zepbound) cut body weight by 20.9% in a 2,539-person trial and semaglutide (Wegovy)…
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Orforglipron vs Wegovy pill: differences, evidence and safety
Orforglipron (Foundayo) and the Wegovy pill (oral semaglutide 25 mg) are both FDA-approved once-daily GLP-1 pills for weight management: Foundayo on April 1, 2026,…
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MOTS-c vs 5-Amino-1MQ: differences, evidence and safety
MOTS-c is a 16-amino-acid peptide encoded in mitochondrial DNA (Lee 2015); 5-amino-1MQ is a small-molecule NNMT inhibitor, not a peptide (Neelakantan 2018). Neither is…
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Tesamorelin for Women: What the Evidence Shows, Side Effects and Safety
Tesamorelin is an FDA-approved prescription drug (Egrifta, approved 2010-11-10) for men and women, but for one use only: reducing excess abdominal fat in adults…
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Survodutide vs Tirzepatide: differences, evidence and safety
Tirzepatide is an FDA-approved GIP/GLP-1 drug, sold as Zepbound for weight management and sleep apnea and as Mounjaro for type 2 diabetes. Survodutide is…