Muscle & Performance
Growth-hormone secretagogues and other peptides studied for muscle, body composition and performance.
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Peptides vs HGH: differences, evidence and safety
HGH is the hormone itself, and it adds lean mass: 2.1 kg in older adults. GH-releasing peptides make the pituitary release its own GH;…
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Best peptides for muscle and fat loss: what the evidence shows, tier by tier
The best-researched peptide for losing fat while keeping muscle is tesamorelin (Egrifta). In its larger phase 3 trial, deep belly fat fell 15.2% on…
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Hexarelin vs Ipamorelin vs Tesamorelin: differences, evidence and safety
Hexarelin, ipamorelin and tesamorelin all make the pituitary release more growth hormone (GH), but their evidence differs sharply. Tesamorelin has the strongest record: it…
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GHRP-2 vs GHRP-6: differences, evidence and safety
Verdict: GHRP-2 (pralmorelin) has the deeper human record: controlled trials and a diagnostic role in Japan. GHRP-6 has older human hormone studies and one…
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MK-677 vs Ipamorelin: differences, evidence and safety
Verdict: MK-677 (ibutamoren) is an oral, non-peptide ghrelin-receptor agonist with several human randomized trials; ipamorelin is an injected five-amino-acid peptide with one published human…
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CJC-1295 with DAC vs without DAC: differences, evidence and safety
Verdict: CJC-1295 with DAC is a long-acting growth hormone–releasing hormone (GHRH) analog with a few small human trials measuring hormone levels. CJC-1295 without DAC…
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Ipamorelin vs Sermorelin vs Tesamorelin: differences, evidence and safety
Verdict: Tesamorelin is an FDA-approved drug (Egrifta WR) for excess abdominal fat in adults with HIV lipodystrophy, backed by phase 3 randomized trials. Sermorelin…
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CJC-1295 vs Ipamorelin: differences, evidence and safety
CJC-1295 is a long-acting GHRH analog whose best result is duration: one injection raised growth hormone 2- to 10-fold for 6 days or more…